In 1616, the 4th Dalai Lama Yundain Gyamco passed away in Zhaibung Monastery, and his incarnation was banned by Dixi Tsangpa. At the time when the Gelug Sect was in a critical phase, Qamzu Soinam Raodain (the abbot of the Gandain Phodrang or the palace of the Dalai Lama in Zhaibung Monastery) and Lobsang Qoigyi Gyaincain (the abbot of Tashilhungpo Monastery) objected to this. The former fled to Qinghai, where he sought military assistance from Mongol Tumet troops. In 1621, Soinam Raodain and Mongol chiefs led some 2,000 mounted troops to defeat the forces of Dixi Tsangpa in Jangtanggang of Lhasa. Dixi Tsangpa was forced to return power to the Gelug Sect and the manors formerly belonging to it, but persisted in banning the incarnation of the 4th Dalai Lama.

In the early 1622, eminent monks practiced divination in front of the Wisdom Buddha for the incarnation of the late 4th Dalai Lama. The chosen soul boy was brought from Nangkaze to Zhaibung Monastery for the sitting-in-the-bed ritual, winning approval from Dixi Tsangpa. As the successor of Dixi Tsangpa and Garma Red-Hat Sect continued to persecute the Gelug Sect, Gushri Khan led his troops into Tibet to assist the Gelug Sect.

Gushri Khan (1582-1655) entered Tibet at the head of 10,000 troops. He controlled the Mongol tribes in Qinghai in 1636 and managed to bring people of the Tibetan ethnic group under his control on the excuse of supporting the Gelug Sect. when he reached Lhasa, the 5th Dalai Lama and some others paid a visit to him.

In 1639, Gushri Khan le his troops from Qinghai to the Kham area on the excuse that Headman Baili in the Kham had persecuted monks of both the Bon religion and Buddhism. By the time Dixi Tsangpa got the news, Headman Baili was already dead and the Kham area was under the rule of Gushri Kham.

In May 1641, Gushri Khan reached Damxung. With guidance from people of the Gelug Sect, he and his troops marched toward the Xigaze area via Namling. Dixi Tsangpa and his men were besieged in their Sangzhuze Castle, which was captured by Gushri Khan in March 1642. as a result, the Dixi Tsangpa Regime, that had existed for 24 years, came to an end.

Gushri Khan greeted the 5th Dalai Lama from Lhasa to Sangzhuze at the end of March 1642, and summoned Pagmo Zhuba and Sagya heads to a rally. During the rally, he announced that 13 10,000-household areas in Tibet belonged to the 5th Dalai Lama and he himself was a benefactor and protector. This rally marked the official founding the coalition regime of the Gelug Sect and Mongol Hoshot tribe in Tibet. In this new regime, Gushri Khan was the Khan who ruled the Qinghai-Tibet Plateau that covered qinghai, the Kham area and Tibet, each of which was controlled by one of his sons. He also gave Sangzhubze the new name of Xigaze. At the end of June, the 5th Dalai Lama and Gushri Khan went to Lhasa. A rally was held in the Norbu Lingka to celebrate the founding of the Gandain Phodrang Regime in Lhasa.

From then on, Tibet's capital moved back to Lhasa and the Xigaze area was left in the hands of the Panchen Erdeni of future generations.